Synthetic Methodology,
Flow Chemistry and Natural Product Synthesis
List of publications as a corresponding author:
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5. Agalave, S. G.; Chaudhari, M. B.; Bisht, G. S.; Gnanaprakasam, B*, Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module, ACS Sustainable Chem. Eng., 2018, 6, 12845−12854.
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4. Chaudhari, M. B.; Moorthy, S.; Patil, S.; Bisht, G. S.; Mohamed, H.; Basu, S.; Gnanaprakasam, B*, Iron-Catalyzed Batch/Continuous Flow C-H Functionalization Module for the Synthesis of Anticancer Peroxides, J. Org. Chem. 2018, 83, 1358-1368.
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​3. Bisht, G. S.; Chaudhari, M. B.; Gupte, V. S.; Gnanaprakasam, B*, Ru-NHC Catalysed Domino Reaction of Carbonyl Compounds and Alcohols: A Short Synthesis of Donaxaridine, ACS Omega, 2017, 2, 8234–8252.
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​​2. Chaudhari, M. B.; Malpathak, S.; Hazra, A and Gnanaprakasam, B*, Transition-Metal Free C-H Hydroxylation of Carbonyl Compounds, Org. Lett., 2017, 19, 3628-3631. (most read article in the month of July-2017 in Organic Letters)
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​​​1. Chaudhari, M. B.; Bisht, G. S.; Kumari, P.; Gnanaprakasam, B*, Ruthenium-Catalyzed Direct α-Alkylation of Amides Using Alcohols, Org. Biomol. Chem., 2016, 14, 9215-9220.
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​Book Chapter/s:
1. 38.0 Peroxides: 38.10 Metal-Catalyzed Synthesis of Peroxides, Gnanaprakasam, B., Chaudhari, M. B., Science of Synthesis Knowledge Updates, (2019) 2, 407; (DOI 10.1055/sos-SD-138-00001).
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​​​List of publications and patents from Post-doc and PhD:
20. Ganapathy, D.; Reiner, J. R.; Löffler, L. E.; Ma, L.; Gnanaprakasam, B.; Niepötter, B.; Koehne, I.; Tietze, L. F. Enantioselective Total Synthesis of Secalonic Acid E. Chemistry A European Journal, 2015, 21, 16807-16810.
19. Pei Shan, S.; Xiaoke, X.; Gnanaprakasam, B.; Dang, T. T.; Ramalingam, B.; Huynh, H. V.; A. M. Seayad, Benzimidazolin-2-ylidene N-heterocyclic carbene complexes of ruthenium as a simple catalyst for the N-alkylation of amines using alcohols and diols. RSC Adv., 2015, 5, 4434-4442.
18. Tietze, L. F.; Ma, L.; Jackenkroll, S.; Reiner, J. R.; Hierold, J.; Gnanaprakasam, B.; Heidemann, S. The Paecilin Puzzle. Enantioselective Synthesis of the Proposed Structures of Paecilin A and B. Heterocycles, 2014, 88, 1101-1119.
17. Gnanaprakasam, B.; Balaraman, E.; Gunanathan, C and Milstein, D. Synthesis of polyamides from diols and diamines with liberation of H2; J. Polym. Sci. part A: Polymer Chemistry, 2012, 50, 1755-1765.
16. Srimani, D.; Balaraman, E.; Gnanaprakasam, B.; Ben-David, Y and Milstein, D. Ruthenium pincer-catalyzed cross-dehydrogenative coupling of primary alcohols with secondary alcohols under neutral conditions; Adv. Synth. Cat., 2012, 354, 2403-2406.
15. Gnanaprakasam, B.; Balaraman, E.; Ben-David, Y and Milstein, D. Synthesis of peptides and pyrazines from β-amino alcohols through extrusion of H2 catalyzed by ruthenium pincer complexes: Ligand-controlled selectivity; Angew. Chem, 2011, 50, 12448-12452.
14. Gnanaprakasam, B and Milstein, D. Direct synthesis of amides from esters with liberation of H2 under neutral conditions; J. Am. Chem. Soc. 2011, 133, 1682-1685.
13. Gnanaprakasam, B, Zhang, J and Milstein, D. Direct Synthesis of imines from alcohols and amines with liberation of H2; Angew. Chem, 2010, 49, 1468-1471.
12. Balaraman, E.; Gnanaprakasam, B; Shimon, L and Milstein, D. Direct hydrogenation of amides to alcohols and amines under mild conditions; J. Am. Chem. Soc. 2010, 132, 16756-16758.
11. Gunanathan, C.; Gnanaprakasam, B; Iron, M. A.; Shimon, L and Milstein, D. Long-range metal ligand cooperation in H2 activation and ammonia-promoted hydride transfer with a ruthenium acridine pincer complex; J. Am. Chem. Soc. 2010, 132, 14763-14765.
10. Gnanaprakasam, B.; Ben-David, Y and Milstein, D. Ruthenium-pincer catalyzed acylation of alcohols using esters with liberation of H2 under neutral conditions; Adv. Synth. Cat. 2010, 352, 3169-3173.
9. Muthusamy, S.: Azhagan, D; Gnanaprakasam, B. and Suresh, E. Diastereoselective synthesis of strained spiro-cyclopropanooxindoles from cyclic Diazoamides; Tetrahedron Lett. 2010, 51, 5662-5665.
8. Muthusamy, S. and Gnanaprakasam, B. Reactions of macrocyclic rhodium carbenoids: regioselective synthesis of indol-3-yl macrocyclic lactones and cryptands; Tetrahedron Lett. 2008, 49, 475-480.
7. Muthusamy, S.; Gnanaprakasam, B and Suresh, E. New approach to the synthesis of macrocyclic tetralactones via ring-closing metathesis using Grubbs’ first-generation catalyst; J. Org. Chem., 2007, 72, 1495-1498.
6. Muthusamy, S. and Gnanaprakasam, B; Insertion reactions of macrocyclic rhodium carbenoids: a novel method for the synthesis of cryptands; Tetrahedron Lett. 2007, 48, 6821-6824.
5. Muthusamy, S. and Gnanaprakasam, B; Tandem reactions of α-diazo ketones with macrocyclic olefins: diastereoselective synthesis of oxanorbornane fused macrocyclic lactones; Tetrahedron 2007, 63, 3355-3362.
4. Muthusamy, S.; Gnanaprakasam, B and Suresh, E. Desymmetrization of cyclic anhydrides using dihydroxy compounds: selective synthesis of macrocyclic tetralactones; Org. Lett. 2006, 8, 1913-1916.
3. Muthusamy, S.; Gnanaprakasam, B. and Suresh, E. Regioselective nucleophilic addition to carbonyl ylide intermediates: a novel diastereoselective synthesis of cycloalkyl fused furan-3-ones; Org. Lett. 2005, 7, 4577-4580.
2. Muthusamy, S. and Gnanaprakasam, B. Ionic liquids as a convenient recyclable medium for the generation of transient carbonyl ylides: Syntheses of oxa and dioxa-bridged polycyclic systems; Tetrahedron 2005, 61, 1309-1315.
1. Muthusamy, S. and Gnanaprakasam, B. Imidazolium salts as phase transfer catalysts for the dialkylation and cyclo-alkylation of active methylene compounds; Tetrahedron Lett. 2005, 46, 635-638.
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Patents
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2. Milstein, D, Balaraman, E, Gnanaprakasam, B, Gunanathan, C and Zhang, J. Use of Ruthenium complexes for Formation and/or Hydrogenation of Amide and related carboxylic acids Derivatives; PCT Int. Appl. 2012, WO 2012/052996.
1. Milstein, D, Gunanathan, C, Ben-David, Y, Balaraman, E, Gnanaprakasam, B and Zhang, J. Novel Ruthenium complexes and their uses in processes for formation and/or Hydrogenation of esters, amides, and derivatives thereof; US patent appl. 2012, US2012/0253042.
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